A home automation (HA) system may include at least one HA operation device and a biometric sensor. The HA system may also include an HA hub device to provide communications for the at least one operation device, and at least one controller. The at least one controller is configured to cooperate with the biometric sensor to monitor a biometric characteristic of a user, store historical operational data for the at least one HA operation device based upon the user, and determine a data trend of the at least one HA operation device based upon the stored historical operational data. The at least one controller may also be configured to correlate the data trend with the biometric characteristic of the user, and use machine learning to predict a health change of the user based upon the correlated data trend and biometric characteristic of the user.