DERIVES D'OESTRONE SUBSTITUES EN 15BETA EN TANT QU'INHIBITEURS SELECTIFSDE 17BETA-HYDROXYSTEROIDES DESHYDROGENASES, LEUR PROCEDE DE PREPARATION ET LEUR UTILISATION
USTAV ORGANICKE CHEMIE A BIOCHEMIE AV CR, V.V.I.;USTAV ORGANICKE CHEMIE A BIOCHEMIE AV CR;HELMHOLTZ ZENTRUM MUNCHEN; V.V.I.;USTAV MOLEKULARNI GENETIKY AKADEMIE VED CR, V.V.I.;UNIVERZITA PALACKEHO V OLOMOUCI
15ß-substituted derivatives of estrone of general formula I wherein R1, R2, R3, R4, R5 are independently selected from the group consisting of: C1-C4 alkyl, C1-C4 alkoxy, C1-C4 halogenalkyl, halogen, COOR6 wherein R6 is C1-C4 alkyl； H, OH； optionally, R3, R4 and R5 are each formed by a hydrogen atom, while R1 and R2 together form an aryl group, preferably naphthyl； wherein the aromatic ring in position C-15 can be mono-, di-, tri-, tetra- and penta- substituted with substituents R1-R5. Compounds of the invention may be used for diagnosis and possibly also for the treatment of estrogen-dependent diseases.
