LIU, HUAQING,BLACK, LAWRENCE A.,BENNANI, YOUSSEF L.,COWART, MARLON D.
申请号：
ES07784511
公开号：
ES2533009T3
申请日:
2007.06.22
申请国别(地区):
ES
年份:
2015
代理人:
摘要：
A compound of the formula: ** Formula ** or a pharmaceutically acceptable salt, ester, or amide thereof, wherein: one of R1 and R2 is a group of the formula -L2-R6a-L3-R6b； the other group of R1 and R2 is selected from the group consisting of hydrogen, alkyl, alkoxy, halogen, cyano, and thioalkoxy； R3, R3a, and R3b are each independently selected from the group consisting of hydrogen, alkyl, trifluoroalkyl, trifluoroalkoxy, alkoxy, halogen, cyano, and thioalkoxy； R4 and R5 are each independently selected from the group consisting of alkyl, fluoroalkyl, hydroxyalkyl, alkoxyalkyl, and cycloalkyl, or R4 and R5 taken together with the nitrogen atom to which each is attached form a non-aromatic ring of the formula : R7, R8, R9, and R10 in each case is independently selected from the group consisting of hydrogen, hydroxyalkyl, fluoroalkyl, cycloalkyl, and alkyl； R11, R12, R13, and R14 are each independently selected from the group consisting of hydrogen, hydroxyalkyl, alkyl, and fluoroalkyl； R6a is selected from the group consisting of a 5-6 membered heteroaryl ring, cyanophenyl, and an 8 to 12 membered bicyclic heteroaryl ring, and a 4 to 12 membered heterocyclic ring； R6b is selected from the group consisting of hydrogen, a 5- to 6-membered heteroaryl ring, an aryl ring, an 8 to 12 membered bicyclic heteroaryl ring, and a 4 to 12 membered heterocyclic ring； Q is O or S； L is - [C (R16) (R17)] k； L2 is selected from the group consisting of a bond, alkylene, -O-, -C (>； = O) -, -S-, -NH-, -N (R16) C (>； = O) -, -C (>； = O) N (R16), and -N (alkyl) -； L3 is selected from the group consisting of a bond, alkylene, -O-, -C (>； = O) -, -S-, -N (R16) C (>； = O) -, -C (>； = O ) N (R16), and -N (R15) -； R15 is selected from the group consisting of hydrogen, alkyl, acyl, alkoxycarbonyl, amido, and formyl； R16 and R17 in each case are independently selected from the group consisting of hydrogen and alkyl； Rx and Ry in each case are independently selected from the group c
