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PREPARATION SOLIDE AYANT UNE MEILLEURE STABILITE A LA LUMIERE.
专利权人:
TORAY INDUSTRIES; INC.
发明人:
TAKAKI, SUGURU,MINAKAMI, SATOSHI,OHTA, KOTOE
申请号:
CA3030392
公开号:
CA3030392A1
申请日:
2017.07.28
申请国别(地区):
CA
年份:
2018
代理人:
摘要:
The purpose of the present invention is to provide a solid preparation which contains a 4,5-epoxymorphinan derivative or a pharmacologically acceptable acid addition salt thereof, and which is stable against light without requiring a light-shielding coating. Provided by the present invention is a solid preparation that contains an active ingredient comprising a 4,5-epoxymorphinan derivative represented by formula (II) or a pharmacologically acceptable acid addition salt thereof, and at least one type of stabilizing agent selected from the group consisting of n-propyl gallate, sodium bisulfite, dibutylhydroxytoluene, butylated hydroxyanisole, tocopherol, and D-isoascorbic acid, wherein: the weight of the active ingredient accounts for 0.00001-0.01 wt% of the weight of the solid preparation; and the weight of the stabilizing agent accounts for 0.005-5 wt% of the weight of the solid preparation.
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中国工程科技知识中心
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