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PRÉPARATION SOLIDE AYANT UNE MEILLEURE STABILITÉ À LA LUMIÈRE.
专利权人:
Toray Industries; Inc.
发明人:
TAKAKI, Suguru,MINAKAMI, Satoshi,OHTA, Kotoe
申请号:
EP17834520
公开号:
EP3492083A4
申请日:
2017.07.28
申请国别(地区):
EP
年份:
2020
代理人:
摘要:
An object of the present invention is to provide a solid preparation comprising a 4,5-epoxymorphinan derivative or a pharmaceutically acceptable acid addition salt thereof, which is stable to light even without light shielding coating. The present invention provides the solid preparation comprising an active ingredient composed of a 4,5-epoxymorphinan derivative as represented below or a pharmaceutically acceptable acid addition salt thereof, and one or more stabilizing agents selected from the group consisting of-propyl gallate, sodium hydrogensulfite, dibutylhydroxytoluene, butylhydroxyanisole, tocopherol and D-isoascorbic acid, wherein the amount of the above active ingredient is 0.00001 to 0.01% by weight of the solid preparation, and the amount of the above stabilizing agent is 0.005 to 5% by weight of the solid preparation.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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