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MEANS FOR TREATING INTESTINAL FIBROSIS
专利权人:
НИТТО ДЕНКО КОРПОРЕЙШН (JP)
发明人:
АЯБИ Токийоши (JP),НАКАМУРА Киминори (JP),МИНОМИ Кенжиро (JP),ТАНАКА Ясунобу (JP)
申请号:
RU2014124430/10
公开号:
RU2014124430A
申请日:
2012.11.16
申请国别(地区):
RU
年份:
2015
代理人:
摘要:
1. A carrier for delivering a substance to cells producing an extracellular matrix in the intestine, a carrier containing a retinoid as a targeting agent for cells producing an extracellular matrix in the intestine. The carrier according to claim 1, wherein the retinoid contains retinol. 3. The carrier according to claim 1 or 2, wherein the carrier comprises a retinoid and a carrier component other than the retinoid, wherein the molar ratio of the retinoid to the carrier component other than the retinoid is from 8: 1 to 1: 4.4. A pharmaceutical composition for treating intestinal fibrosis, comprising a carrier according to any one of claims. 1-3 and a drug for monitoring the activity or growth of cells producing an extracellular matrix in the intestine. 5. A pharmaceutical composition for regenerating normal intestinal tissue from intestinal fibrous tissue, comprising a carrier according to any one of claims. 1-3 and a drug for monitoring the activity or growth of cells producing an extracellular matrix in the intestine. 6. The pharmaceutical composition of claim 4 or 5, wherein the medicament for controlling the activity or growth of cells producing an extracellular matrix in the intestine is selected from the group consisting of a substance for inhibiting the production and secretion of an extracellular matrix component, a cell growth inhibitor, an apoptosis inducing substance, TIMP inhibitor and α1-antitrypsin inhibitor. 7. The pharmaceutical composition of claim 6, wherein the substance for inhibiting the production and secretion of an extracellular matrix component is an HSP47.8 inhibitor. The pharmaceutical composition according to any one of paragraphs. 4-7, where the composition is in the form obtained at the time of use. Set to receive1. Носитель для доставки вещества к клеткам, продуцирующим внеклеточный матрикс в кишечнике, носитель, содержащий ретиноид в качестве нацеливающего средства для клеток, продуцирующих внеклеточный матрикс в кишечнике.2. Носител
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中国工程科技知识中心
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http://www.ckcest.cn/home/

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