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СОЕДИНЕНИЯ ДЛЯ ЛЕЧЕНИЯ ВИДОВ РАКА, АССОЦИИРОВАННЫХ С ПАПИЛЛОМАВИРУСОМ ЧЕЛОВЕКА
专利权人:
ПИРАМАЛ ЭНТЕРПРАЙЗИС ЛИМИТЕД
发明人:
ПИРАМАЛ Свати Аджай,ПАДИГАРУ Муралидхара,АГАРВАЛ Веена Р.,ДЕШПАНДЕ Гандхали Ашвин
申请号:
RU2014102089
公开号:
RU2014102089A
申请日:
2012.06.22
申请国别(地区):
RU
年份:
2015
代理人:
摘要:
1. A compound of formula (I) or a pharmaceutically acceptable salt, solvate, stereoisomer or diastereoizomeragde Ar represents a phenyl group which is unsubstituted or substituted with 1, 2 or 3 identical or different substituents selected from halogen, nitro, cyano, CC- alkyl, trifluoromethyl, hydroxy and CC-alkoxy, in the manufacture of a medicament for treating cancers associated with human papillomavirus (HPV) .2. Use according to claim. 1, where Ar represents a phenyl group substituted with 1, 2 or 3 identical or different substituents selected from chlorine, bromine, fluorine, iodine, CC-alkyl and triftormetila.3. Use according to Claim. 1 or 2, wherein Ar represents a phenyl group substituted hlorom.4. Use according to Claim. 1 or 2, wherein Ar represents a phenyl group substituted by chlorine and triftormetilom.5. Use according to claim 1, wherein the compound of formula (I) is (+.) - trans-isomer represented by formula (IA), or a pharmaceutically acceptable salt or solvate thereof, wherein Ar represents a phenyl group which is unsubstituted or substituted with 1, 2 or 3 identical or different substituents selected from halogen, nitro, cyano, CC-alkyl, trifluoromethyl, hydroxyl or CC-alkoksi.6. Use according to claim 5, wherein the compound of formula (IA) is the hydrochloride (+.) - trans-2- (2-chlorophenyl) -5,7-dihydroxy-8- (2-hydroxymethyl-1-methylpyrrolidin-3-yl) - chromen-4-one (compound A) .7. Use according to claim 5, wherein the compound of formula (IA) is the hydrochloride (+.) - trans-2- (2-chloro-4-trifluoromethylphenyl) -5,7-dihydroxy-8- (2-hydroxymethyl-1-methylpyrrolidin-3 -yl) chromen-4-one (B) .8 compound. Use according to claim. 1, where the cancer-associated HPV sps1. Применение соединения формулы (I) или его фармацевтически приемлемой соли, сольвата, стереоизомера или диастереоизомерагде Ar представляет собой фенильную группу, которая является незамещенной или замещенной 1, 2 или 3 идентичными или различными заместителями, выбранными из г
来源网站:
中国工程科技知识中心
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