Refers to - amide substituted Spiro compounds of formula (i) where a is 0 and 1, B is 0 to 2 t is 1 to 3 c, D, e and F are each from 0 to 2 d is one of the radical D1 or D2, where Q and s are each 0 OR 1 R is 1 to 3, B - C (= o), S (= o) 2, among others Q1 and Q2 are each C CH o n r1 is alkyl (C1 - C6), aryl, heteroaryl, among others R2 is H, alkyl (C1 - C6)Cycloalkyl (C3, C8), among others R3 and R4 with - Q1 - Q2 - form a Ring of 4 to 7 members R5 IS F, CL, Oh, ocf3, CF3, among others R6 F, CF3, alkyl (C1 - C6), NO2, among others and R7 R8 are Each = F, Oh, o, alkyl (C1 - C6), among others X is o, nr11, among others and it is, or NR13, among others. Where are R11 and R13 each h, alkyl, cycloalkyl (C1 - C6) (C3, C8), among others Z is o, NR15,Among others, where R15 is H, alkyl, aryl (C1 - C10), among others. Preferred compounds are: 7 - chlorine - 2 - [6 - (9 - pyridin-4-yl - 3.9 - diazaespiro [5.5] UNDECANE - 3 - carbonyl) - 2,3 dihydro - 1H inden - triazin-1-yl] - 2.3 - dihydro - 1 - isoindol ona n - [6 - [9 - (azetidin - 1 - il) - 3 - azaespiro [5.5] carbonyl] - UNDECANE - 3 - 2,3 dihydro - 1H inden - triazin-1-yl] - 2 - chlorine - chlorine - benzamide 7 - 2 - [(1S) - 8 - 7 - (pyridin-4-yl - 3.8 - di Azaespiro [4.5] Dean - 3 - carbonyl) - 1,2,3,4 - tetrahydro - naphthalene - triazin-1-yl] - 2.3 - dihydro - 1 - isoindol ona among others. It also relates to a Pharmaceutical composition. These compounds are modulators of bradykinin receptor 1 (B1R) being useful in the treatment of acute pain, migrana, diabetes, ObesitySE REFIERE A COMPUESTOS DERIVADOS DE ESPIRO-AMIDA SUSTITUIDO DE FORMULA (I) DONDE a ES 0 A 1 b ES DE 0 A 2 t ES DE 1 A 3 c, d, e Y f SON CADA UNO DE 0 A 2 D ES UNO DE LOS RADICALES D1 O D2, EN DONDE q Y s SON CADA UNO 0 O 1 r ES DE 1 A 3 B ES C(=O), S(=O)2, ENTRE OTROS Q1 Y Q2 SON CADA UNO C, CH O N R1 ES ALQUILO(C1-C6), ARILO, HETEROARILO, ENTRE OTROS R2 ES H, ALQUILO(C1-C6), CICLOALQUILO(C3-C8), ENTRE OTROS R3 Y R4 JUNTO CON -Q1-Q2- FORMAN UN ANILL
