DANIEL L FLYNN U S A,MICHAEL D KAUFMAN U S A,WILLIAM C PATT U S A,PETER A PETILLO U S A
申请号：
IN2717/MUMNP/2011
公开号：
IN2011MN02717A
申请日:
2011.12.15
申请国别(地区):
IN
年份:
2012
代理人:
摘要：
The present invention relates to novel kinase inhibitors and modulator compounds useful for the treatment of various diseases. More particularly the invention is concerned with such compounds kinase/compound adducts methods of treating diseases and methods of synthesis of the compounds. Preferrably the compounds are useful for the modulation of kinase activity of Raf kinases and disease polymorphs thereof. Compounds of the present invention find utility in the treatment of mammalian cancers and especially human cancers including but not limited to malignant melanoma colorectal cancer ovarian cancer papillary thyroid carcinoma non small cell lung cancer and mesothelioma. Compounds of the present invention also find utility in the treatment of rheumatoid arthritis and retinopathies including diabetic retinal neuropathy and macular degeneration.
