Peter A. Petillo;William C. Patt;Daniel L. Flynn;Michael D. Kaufman
发明人:
Daniel L. Flynn,Peter A. Petillo,Michael D. Kaufman,William C. Patt
申请号：
US11854354
公开号：
US08188113B2
申请日:
2007.09.12
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The present invention relates to novel dihydropyridopyrimidinyl, dihydronaphthyridinyl, and related compounds which are kinase inhibitors and modulator useful for the treatment of various diseases. More particularly, the invention is concerned with such compounds, kinase/compound adducts, methods of treating diseases, and methods of synthesis of the compounds. Preferably, the compounds are useful for the modulation of kinase activity of Raf kinases and disease polymorphs thereof. Compounds of the present invention find utility in the treatment of mammalian cancers and especially human cancers including but not limited to malignant melanoma, colorectal cancer, ovarian cancer, papillary thyroid carcinoma, non small cell lung cancer, and mesothelioma. Compounds of the present invention also find utility in the treatment of rheumatoid arthritis and retinopathies including diabetic retinal neuropathy and macular degeneration.
