The present invention discloses a tissue collection device and the methods of making and using the same. The tissue collection device comprises a vacuum chamber or vacuum lid in conjunction with a disposable tissue filtration system. The vacuum chamber or vacuum lid has a mechanism to allow the vacuum chamber or vacuum lid to receive and open to the disposable tissue filtration system and re-seal to allow tissue/fluid to be aspirated directly in the disposable tissue filtration system via an external vacuum source.
