BRAVO, YALDA MOSTOFI,STOCK, NICHOLAS SIMON,JACINTHO, JASON DUARTE,CHEN, AUSTIN CHIH-YU
申请号：
PE0003232016
公开号：
PE08802016A1
申请日:
2014.09.04
申请国别(地区):
PE
年份:
2016
代理人:
摘要：
Refers to compounds of formula Ia and IB, and pharmaceutically acceptable salts of the same, which is piridilo A1 or A2 is phenyl, phenyl Ring of 6 members, a heteroaromatico containing 1, 2 or 3 n ATOMS, or a Ring of five members heteroaromatico containing 1, 2, 3 or 4 heteroato We independently selected from o, s and N, among others X is - (CH2) or - (CH2) m\u2013nh\u2013 meters (CH2) n\u2013,Where M and N are independently 0, 1, 2, 3 or 4, and M + N is 2, 3 or 4 R1 and R2 are independently h, halogen, CN, CF3, c1\u20136 alkyl or cycloalkyl c3\u20136, among others c1\u20136 R5 is alkyl, aryl, heteroaryl, or cycloalkyl c3\u20136 alquenilo c2\u20136, among others and R6 is aryl or heteroari What,Each optionally replaced with 1 or 2 independently selected from Halogen substituents, NO2, CF3, ocf3, alkyl c1\u20136 or CN, among others. It also relates to pharmaceutical compositions comprising such compounds of formula Ia or IB, or salts thereof.The compounds of the invention are antagonists of Dual PPAR alpha and PPAR Delta, which are useful in the treatment of cancers of the Prostate, Breast, Colon, pancreatic, Human Chronic Lymphocytic Leukemia, melanoma and other. Furthermore, they are also useful in the treatment of Viral Infections, such as Infections by HCV and HIV infections.Se refiere a compuestos de formulas Ia y Ib, y sales farmaceuticamente aceptables de los mismos, en los cuales A1 es fenilo o piridilo A2 es fenilo, un anillo heteroaromatico de 6 miembros conteniendo 1, 2 o 3 atomos de N, o un anillo heteroaromatico de 5 miembros conteniendo 1, 2, 3 o 4 heteroatomos independiente seleccionados de O, S y N, entre otros X es –(CH2)m– o –(CH2)m–NH–(CH2)n–, en donde m y n son independientemente 0, 1, 2, 3 o 4, y m + n es 2, 3 o 4 R1 y R2 son independientemente H, halogeno, CN, CF3, alquilo C1–6 o cicloalquilo C3–6, entre otros R5 es alquilo C1–6, arilo, heteroarilo, cicloalquilo C3–6 o alquenilo C2–6, entre otros y R6 es arilo o heteroarilo, cada uno de ellos o
