The present invention relates to a method of producing an orotate salt of the pharmaceutical compound characterized in that the said method comprises reacting a water-insoluble pharmaceutical compound having an ionizable center capable of reacting with orotic acid or an alkali salt of orotic acid, wherein said pharmaceutical compound is selected from the group consisting of acetanilide, adriamycin, anilide, anthracycline antibiotic, benzodiazepine, cephalosporine, colchicines, cyclophosphamide, digitalis glycoside, dihydropyridine,epiphodophyllotoxin, epirubicin, ergot alkaloid, fluorouracil, macrolide, nitrogen mustard, phenothiazine, phenylpiperidine, piperazine, piperidine, pyrimidine, retinoid, sulfonylurea, tamoxifen, -vinblastine or vinca alkaloid, and, wherein the orotate salt of the pharmaceutical compound selected shows increased absorption and bioavailability.
