The present invention relates generally to the method of increasing the oralbioavailability, reducing chemotherapy induced toxicity and side effects,and improving the effectiveness of pharmaceutical agents that are poorly absorbedfrom the gastrointestinal tract. Specifically, the invention relates to poorlyabsorbed pharmaceutical drugs and converting them to orotate salts. The orotatesalts of the drugs can be dosed at lower doses to provide the efficacy benefitsof a higher dose, while reducing the drugs toxic effects at lower doses. Additionally,the orotate salts of pharmaceutical agents have better clearance and reducethe potential for drug-induced hepatic toxicity. Therefore, an especiallyuseful formulation of the orotate salt of the pharmaceutical agent can providerapid and consistent action using a lower dose while reducing drug interactionsand side-effects.
