Matthew R. Pincus;Ehsan Sarafraz-Yazdi;Josef Michl
发明人:
Matthew R. Pincus,Josef Michl,Ehsan Sarafraz-Yazdi
申请号：
US13122256
公开号：
US08822419B2
申请日:
2009.10.02
申请国别(地区):
US
年份:
2014
代理人:
摘要：
An aspect of the invention provides a method of selectively necrosing cells, comprising: providing a plurality cells, including at least one cancer cell and at least one non-cancerous cell； and administering to the cells a compound, including an HDM-2 targeting component and a cytotoxic component attached to the HDM-2 targeting component, wherein said compound comprises a membrane-active form.
