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Ablation immunotherapy
专利权人:
イミュノバティブ;セラピーズ,リミテッド
发明人:
ハル-ノイ,マイケル
申请号:
JP2016500938
公开号:
JP6538647B2
申请日:
2014.03.10
申请国别(地区):
JP
年份:
2019
代理人:
摘要:
The disclosure herein relates generally to immunotherapy and, more specifically, to the use of immunotherapy for treating tumors and pathogen infected tissues. The immunotherapy relates to first priming patients with allogeneic cells designed to be rejected by a Thl mediated mechanism, then inducing in situ necrosis or apoptosis in a tumor or pathogen infected lesion. Necrosis or apoptosis can be induced by methods such as cryotherapy, irreversible electroporation, chemotherapy, radiation therapy, ultrasound therapy, ethanol chemoablation, microwave thermal ablation, radiofrequency energy or a combination thereof applied against at least a portion of the tumor or pathogen infected tissue. One or more doses of allogeneic cells (e.g., Thl cells) are then delivered within or proximate to the tumor or pathogen-infected tissue in the primed patient. The present invention provides an immunotherapeutic strategy to develop de-novo systemic (adaptive) immunity to a tumor or pathogen.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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