Various devices, methods, and systems to implant and secure a fusion cage or intervertebral prosthesis during treatment of spinal injury or disease are provided. In various embodiments, such devices may comprise an instrument assembly having a body comprising a head, a shaft, and a handle; an insertion stop; and an intervertebral device retainer. Various embodiments also may comprise an impactor assembly comprising a housing; a bit comprising a head, a shaft, and a coupler; a transmission comprising a housing, a cam, a cam follower, a collet, and a driveshaft; and the motor. In various embodiments, the impactor assembly may be deployed with adjustments for the frequency, displacement, and force of impulses delivered to an anchor for the intervertebral device.