The present invention is related to pharmacology, medicine, veterinary science and pharmaceutical industry, in particular to the process of production original composite antimicrobial and anti-inflammatory preparations for parenteral administration having an increased therapeutic efficiency in the treatment of severe forms of infectious inflammatory diseases.The claimed pharmaceutical composition contains fosfomycin and finely dispersed nanostructured silica dioxide active agents. The claimed process for the production of a pharmaceutical composition includes mixing fosfomycin with finely dispersed nanostructured silica dioxide, characterized in that the mixture of said substances in a weight ratio from 10:1 to 70:1 respectively is being exposed to mechanical treatment by impact and abrasive actions to increase the weight percentage of the finely dispersed fraction (≤ 5 micron) to at least 25%. The received mixture is used to prepare for injection solutions.
