KUNZ, ARTHUR,MORAN, JUSTIN KEITH,RUBINO, JOSEPH THOMAS,JAIN, NEERA,VIDUNAS, EUGENE JOSEPH,SIMPSON, JOHN MCLEAN,ROBBINS, PAUL,MERGIANT, NISHITH,DIJOSEPH, JOHN FRANCIS,RUPPEN, MARK EDWARD,DAMLE, NITIN K
申请号：
NZ58607103
公开号：
NZ586071A
申请日:
2003.05.02
申请国别(地区):
NZ
年份:
2012
代理人:
摘要：
Disclosed is a monomeric calicheamicin derivative/anti-CD22 antibody conjugate having the formula, Pr (-X-S-S-W)m wherein: Pr is an anti-CD22 antibody； X is a hydrolyzable linker that comprises a product of any reactive group that can react with an antibody； W is a calicheamicin radical； m is the average loading for a purified conjugation product such that the calicheamicin constitutes 4-10% of the conjugate by weight； and (-X-S-S-W)m is a calicheamicin derivative, wherein the antibody molecule comprises a heavy chain variable domain comprising (a) SEQ ID NO: 1 for CDR-H1, (b) SEQ ID NO: 2 or SEQ ID NO: 13 or SEQ ID NO: 15 or SEQ ID NO: 16 or residues 50- 66 of SEQ ID NO: 27 for CDR-H2, and (c) SEQ ID NO: 3 for CDR-H3； and a light chain variable domain comprising (d) SEQ ID NO: 4 for CDR-L1, (e) SEQ ID NO: 5 for CDR-L2, and (f) SEQ ID NO: 6 for CDR-L3.
