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FORMULATIONS DE MEDICAMENT RESISTANTES AUX ABUS AVEC PROTECTION INTEGREE CONTRE LE SURDOSAGE
专利权人:
KASHIV PHARMA LLC
发明人:
VAKA, SIVA RAM KIRAN,CHATTERJI, ASHISH,DESAI, DIPEN,PHUAPRADIT, WANTANEE,SHAH, NAVNIT H.,THONGSUKMAK, ATSAWIN,MEGHPARA, KANJI
申请号:
CA2938699
公开号:
CA2938699A1
申请日:
2015.02.05
申请国别(地区):
CA
年份:
2015
代理人:
摘要:
Disclosed are solid oral pharmaceutical compositions that that are intended to provide protection against overdose and tampering, as well as abuse deterrence. The compositions contain a plurality of granules or multi-particulates. A first population of multi particulates contains an API or drug susceptible to abuse, a polymer matrix, and an outer coating that contains a cationic pH dependent polymer. These multi particulates also contain a plasticizer and a surfactant. A second population of multi particulates contains a viscosity building polymer and an alkaline buffering agent. Compositions may further include a disintegrant, and/or additional viscosity building polymers and/or alkaline buffering agents and/or ion exchange polymers. Also disclosed are the methods of making and using the compositions.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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