PROBLEM TO BE SOLVED: To provide a cancer treatment method that is more effective than and replaces the conventional antibody therapy in order to treat cancer or prevent cancer relapse or metastasis.SOLUTION: The present invention provides a method that exhibits a synergistic effect in cancer treatment by combination use of an anti-epiregulin antibody with an anti-EGFR antibody, as compared to the conventional treatment with the anti-EGFR antibody alone. There is also provided a method for treating cancer or preventing cancer relapse or metastasis.SELECTED DRAWING: Figure 1COPYRIGHT: (C)2020,JPO&INPIT【課題】癌を治療する、または癌の再発もしくは転移を抑制するため、従来の抗体治療に代わる、より有効な癌治療法の提供。【解決手段】抗Epiregulin抗体を抗EGFR抗体と併用することによって、抗EGFR抗体単独による処置と比べて、癌の治療において相乗的な効果を得られる方法。癌の治療又は癌の再発或いは転移を抑制する方法【選択図】図1