Iowa State University Research Foundation, Inc.;University of Iowa Research Foundation
发明人:
Balaji NARASIMHAN,Kathleen A. Ross,Kevin L. Legge,Thomas J. Waldschmidt
申请号：
US16370444
公开号：
US20190365887A1
申请日:
2019.03.29
申请国别(地区):
US
年份:
2019
代理人:
摘要：
Immunogenic compositions and methods of using them include a biodegradable or bioerodible polyanhydride nanoparticle comprising 1,8-bis(p-carboxyphenoxy)-3,6-dioxaoctane (CPTEG) and 1,6-bis(p-carboxyphenoxy)hexane (CPH) copolymers, an immunogenic protein of an Influenza Virus and an adjuvant entrapped within an interior of the nanoparticle, and an excipient. The immunogenic composition may be administered to a subject to confer both local and systemic immunity to the Influenza Virus.
