N- [4- (2-OXO-1,2-DIHYDRO-PYRIDIN-4-YL) -BENZYL] -BENZAMIDE DERIVATIVES SUCH AS ALDH-2 INHIBITORS FOR TREATMENT OF DEPENDENCE

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专利权人:

Amygdala Neurosciences; Inc.

发明人:

GRAUPE, Michael,GUERRERO, Juan, A.,STICKLEY, Robert, G.,VENKATARAMANI, Chandrasekar,ZABLOCKI, Jeff,CANNIZZARO, Carina E.,LU, Yafan

申请号：

DK15184883

公开号：

DK2993170T3

申请日:

2012.06.29

申请国别(地区):

DK

年份:

2018

代理人:

摘要：

Disclosed are N-[4-(2-oxo-1,2-dihydro-pyridin-4-yl)-benzyl]-benzamide derivatives which are useful as human mitochondrial aldehyde dehydrogenase (ALDH-2) inhibitors for treating chemical dependency on dopamine-producing agents such as cocaine, opiates, amphetamines, nicotine and alcohol. Also disclosed are pharmaceutical compositions comprising a therapeutically effective amount of said compounds and methods of using the compounds in the treatment of addiction.

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