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Substituted indolo [2,3-a] quinolizines in the treatment of cancer
专利权人:
发明人:
申请号:
EP11075135.1
公开号:
EP2532664A1
申请日:
2011.06.09
申请国别(地区):
EP
年份:
2012
代理人:
摘要:
The present invention relates to novel substituted indolo [2,3-a] quinolizines of the general formula (I)and stereoisomeric forms thereof and/or pharmaceutically acceptable salts of these compounds as well as pharmaceutical compositions containing at least one of these substituted indolo [2,3-a] quinolizines together with pharmaceutically acceptable carrier, excipient and/or diluents. Said novel substituted indolo [2,3-a] quinolizines have been identified as useful for the prophylaxis and treatment of cancer by the induction of strong mitotic delays, chromosomal misalignments and mitotic tri- and multipolarization leading to cell cycle stop and apoptosis. Furthermore a synthesis for preparation of the substituted indolo [2,3-a] quinolizines is disclosed in the present invention.
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