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SUBSTITUTED INDOLO [2,3-A] QUINOLIZINES
专利权人:
Slava Ziegler;Kamal Kumar;Vivek Khedkar;Katja Hübel;Sascha Menninger;Heiko Dückert;Verena Pries;Hanna Bruss;Herbert Waldmann;Vincent Eschenbrenner
发明人:
Herbert Waldmann,Kamal Kumar,Katja Hübel,Verena Pries,Heiko Dückert,Sascha Menninger,Slava Ziegler,Hanna Bruss,Vivek Khedkar,Vincent Eschenbrenner
申请号:
US13408616
公开号:
US20120316192A1
申请日:
2012.02.29
申请国别(地区):
US
年份:
2012
代理人:
摘要:
The present invention relates to novel substituted indolo[2,3-a]quinolizines and stereoisomeric forms thereof and/or pharmaceutically acceptable salts of these compounds as well as pharmaceutical compositions containing at least one of these substituted indolo[2,3-a]quinolizines together with pharmaceutically acceptable carrier, excipient and/or diluents. Said novel substituted indolo[2,3-a]quinolizines have been identified as useful for the prophylaxis and treatment of cancer by the induction of strong mitotic delays, chromosomal misalignments and mitotic tri- and multipolarization leading to cell cycle stop and apoptosis. Furthermore a synthesis for preparation of the substituted indolo[2,3-a]quinolizines is disclosed in the present invention.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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