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Nanoparticles containing a pH sensitive peptide
专利权人:
Taiho Pharmaceutical Co.; Ltd.
发明人:
KOGURE, Kentaro,HAMA, Susumu
申请号:
ES12777710
公开号:
ES2654057T3
申请日:
2012.04.24
申请国别(地区):
ES
年份:
2018
代理人:
摘要:
A peptide compound represented by the following Formula (II): R1- (Z1) l- [His- (AA1) (AA2) (AA3) - Glu / Asp] n- (Z2) m-R2 (II), wherein His is histidine; Glu / Asp is a glutamic acid or aspartic acid; AA1, AA2 and AA3 are the same or different and each represents Gly, Ala, His, Leu, Ile, Val, Phe, Tyr, Trp, Cys, Met, Ser, Thr, Gln or Asn; n represents an integer from 2 to 8; l and m are the same or different and each represents 0 or 1; R1 is a C12-24 hydrocarbon group or a C12-24 acyl group; R2 is OH or a C-terminal protecting group; and Z1 or Z2 represents a linker consisting of 1 to 8 amino acids selected from Gly, Ala, Leu, Ile, Val, Phe, Tyr, Trp, Cys, Met, Ser, Thr, Gln, and Asn, containing the peptide compound 10 to 60 amino acids in total.Un compuesto peptídico representado por la Fórmula (II) siguiente: R1-(Z1)l-[His- (AA1) (AA2) (AA3) - Glu/Asp]n-(Z2)m-R2 (II), en donde His es histidina; Glu/Asp es un ácido glutámico o ácido aspártico; AA1, AA2 y AA3 son iguales o diferentes y cada uno representa Gly, Ala, His, Leu, Ile, Val, Phe, Tyr, Trp, Cys, Met, Ser, Thr, Gln o Asn; n representa un número entero de 2 a 8; l y m son iguales o diferentes y cada uno representa 0 o 1; R1 es un grupo hidrocarbonado C12-24 o un grupo acilo C12-24; R2 es OH o un grupo protector C-terminal; y Z1 o Z2 representa un enlazador que consiste en 1 a 8 aminoácidos seleccionados de Gly, Ala, Leu, Ile, Val, Phe, Tyr, Trp, Cys, Met, Ser, Thr, Gln, y Asn, conteniendo el compuesto peptídico 10 a 60 aminoácidos en total.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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