The present invention provides a probe with multipurpose features, a system and a method for using the probe for intracerebral guidance during stereotactic tumour biopsy. The probe is essentially tube shaped and accommodate optical fibres, wherein at least one optical fibre pair is arranged in close proximity towards the proximal end (P), wherein at least one fibre of the fibre pair is operatively connected via the distal end (D) to a blue laser light source and/or a light source in the red or near infrared region and/or a white light for the DRS, and a detector unit.By using the probe for localizing and imaging a tumour before performing a biopsy of the tumour for diagnosis, use of said probe significantly reduces the risk that the biopsy is removed from a part not reflecting the actual tumor tissue. Moreover, the risk to cause hemorrhage in the track is significantly reduced due the combined vessel tracking feature in the probe.
