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Water-soluble polymer-based cantharimides as potentially selective anti-tumor agents
专利权人:
Johnny Cheuk-on Tang
发明人:
Johnny Cheuk-on Tang,Albert Sun-chi Chan,Kim-hung Lam,Chung-hin Chui,Stanton Hon Lung Kok,Marcus Chun Wah Yuen,Sau Hing Chan,Chor Hing Cheng,Filly Cheung
申请号:
US12428488
公开号:
US08344007B2
申请日:
2009.04.23
申请国别(地区):
US
年份:
2013
代理人:
摘要:
A cantharimide compound may include the backbone of formula (1). R1, R2, R3, and R4 may be independently selected from the group consisting of H, C(O)OR5, C(O)R6, C(O)NR7R8, NR9C(O)R10, N—R11R12, O—R13, S—R14, P(O)(OR15)(OR16), As(O)(OR17)(OR18), SO2R19, SO3R20, and B(OR21). X1 to X4 may be independently selected from the group consisting of nitrogen and carbon, such that X1 to X4 are not all hydrogen. Y1, Y2 and R5 to R21 may be independently selected from the group consisting of hydrogen, C1-12-alkyl, -aryl, heteroaryl, and a bioactive polymer.
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