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Arsenoplatin anti-cancer agents
专利权人:
发明人:
Denana U. Miodragovic,Thomas V. OHalloran
申请号:
US15637179
公开号:
US10118938B2
申请日:
2017.06.29
申请国别(地区):
US
年份:
2018
代理人:
摘要:
Disclosed herein are methods of treating a cancer cell that include contacting a cancer cell with a compound having the structure of formula (I)M is Pt, Pd or Ni Q is As, Sb or Bi Z1 is N Z2 is O or S L1 and L2 are independently C(O), C—R1 or C—R2 X is a Lewis base Y1 and Y2 are independently selected from —OR3, —OR4, —SR3 and —SR4, wherein R1 and R2 are independently selected from hydrogen, halogen, cyano, keto, ester, ether, thiol, thioether, thioester, imino, C1-C10 alkyl, C1-C10 alkenyl, alkynyl, alkoxyl, amino, amidyl, immino, sulfonyl, sulfoxyl, phosphoryl, phosphoryl ester, glycosyl, aryl, C3-C15 cycloalkyl, heteroaryl, and C3-C15 heterocycloalkyl and R3 and R4 are independently selected from hydrogen, C1-C10 alkyl, C1-C10 alkenyl, alkynyl, alkoxyl, amino, amidyl, immino, sulfonyl, sulfoxyl, phosphoryl, phosphoryl ester, glycosyl, aryl, C3-C15 cycloalkyl, heteroaryl, and C3-C15 heterocycloalkyl.
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