Zhong, Zhenshao,Perkins, Melissa D.,Friemuth, William,Odenheimer, Daniel,Chevrier, Marc
申请号:
AU2006344395
公开号:
AU2006344395B2
申请日:
2006.10.05
申请国别(地区):
AU
年份:
2013
代理人:
摘要:
The present invention relates to methods and compositions for use in treatmentof patients with autoantibody positive disease. In a specific embodiment, thepresent invention relates to a method of treating a patient that has an ANA titerof 1:80 or greater and/or greater than or equal to 30 IU/ml of anti-dsDNA antibodiesin his/her blood plasma or serum comprising administering a therapeuticallyeffective amount of an immunomodulatory agent, such as an antagonist of Neutrokine-alpha.Additionally provided is a method of reducing the frequency and/or quantityof corticosteroid administration to patients. In preferred embodiments, thepatient has systemic lupus erythematosus. Methods for determining if a lupuspatient is responding to medical treatment are also provided.