This invention, jiashiruguriseroruashirutoransuhueraze ( DGAT ) as an obstruction medicine the medicine composition, and the heart blood vessel disease which include the new hetero cyclic compound and the said hetero cyclic compound, metabolism characteristic obstacle and obesity or obesity-related obstacle, diabetes and the lipid abnormal symptom, the diabetes characteristic complication, resistance sugar talent abnormality or the hungry time regards the use of the said chemical compound in order it remedies or to prevent blood glucose abnormality, or. The illustrate chemical compound of this invention is shown on description below.本発明は、ジアシルグリセロールアシルトランスフェラーゼ(”DGAT”)阻害薬としての新規ヘテロ環式化合物、該ヘテロ環式化合物を含む医薬組成物、及び、心臓血管疾患、代謝性障害、肥満若しくは肥満関連障害、糖尿病、脂質異常症、糖尿病性合併症、耐糖能異常又は空腹時血糖異常を治療又は予防するための該化合物の使用に関する。本発明の例示的な化合物が下記に示されている。