Problem to be solved: to provide a novel transdermal absorption composition that uses a low molecular weight gelator to improve the feeling of use and percutaneous absorption.Solution (1) a compound of formula (1) and a lipid peptide type compound comprising a pharmaceutically available salt thereof, an active ingredient selected from a surfactant, polyvalent alcohol, fatty acid, hyaluronic acid and insulin, and a percutaneous absorption composition comprising water.In formula (R1), R1 is an aliphatic group of 9 to 23 carbon atoms, R2 is an alkyl group having 1 to 4 carbon atoms capable of having a hydrogen atom or a branched chain of 1 or 2 carbon atoms, R3 is - (CH2) N-X group, n is 1 to 4, X is an amino group, guanidino group, - CONH2 base, or nitride A group consisting of five membered or six membered ring groups or a fused heterocyclic group consisting of five membered and six membered rings capable of having one to three atom atoms.No selection【課題】低分子ゲル化剤を用い、使用感及び経皮吸収性の向上を図った新規な経皮吸収組成物の提供。【解決手段】式（１）の化合物及びその類似化合物又はそれらの薬学的に使用可能な塩からなる脂質ペプチド型化合物、界面活性剤、多価アルコール、脂肪酸、ヒアルロン酸及びインスリンから選択される有効成分、及び水を含む経皮吸収組成物。（式中、Ｒ１は炭素原子数９乃至２３の脂肪族基、Ｒ２は水素原子又は炭素原子数１若しくは２の分枝鎖を有し得る炭素原子数１乃至４のアルキル基、Ｒ３は－（ＣＨ２）ｎ－Ｘ基、ｎは１乃至４の数、Ｘはアミノ基、グアニジノ基、－ＣＯＮＨ２基、又は窒素原子を１乃至３個有し得る５員環基若しくは６員環基又は５員環と６員環から構成される縮合複素環基。）【選択図】なし
