The invention relates to dihydroorate dehydrogenase (DHODH) inhibitors useful for the treatment of neurodegenerative diseases, such as amyotrophic lateral sclerosis.La invención se refiere a inhibidores de dihidroorato deshidrogenasa (DHODH) útiles para el tratamiento de enfermedades neurodegenerativas, tales como la esclerosis lateral amiotrófica.