Thermally-targeted delivery of medicaments including doxorubicin

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专利权人:

Drazen Raucher

发明人:

Drazen Raucher,Gene Bidwell, III,Waldemar Priebe,Izabela Fokt

申请号：

US12162283

公开号：

US08252740B2

申请日:

2007.01.29

申请国别(地区):

US

年份:

2012

代理人:

摘要：

Elastin-like polypeptide (ELP) serves as a vector for thermally-targeted delivery of therapeutics, including cytotoxic chemotherapeutic drugs such as doxorubicin. Examples of an ELP-based delivery vehicle can comprise: (1) a cell penetrating peptide, such as a Tat peptide, (2) ELP, and (3) the lysosomally degradable glycylphenylalanylleucylglycine (GFLG) (SEQ ID NO: 3) spacer and a cysteine residue (SEQ ID NO: 4) conjugated to therapeutic such as doxorubicin, or an analog thereof.

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