Antibodies and antigen binding fragments directed against Staphylococcus aureus (S. aureus) surface determinant antigens and bi- specific antibodies comprising the antibodies or binding fragments that also bind to secreted toxins are disclosed. Methods of detecting, diagnosing and treating S. aureus infection using the antibodies and antigen binding fragments are also provided. Further disclosed are heavy chain variable region (VH) and light chain variable region (VL) region sequences of the antibodies.
