Devices and methods are provided herein for aiding in the diagnosis of and response to conditions ranging from unpleasant to disabling. Images are presented to viewers and eye-tracking of their eyes during that process along with software analysis non-subjectively identify and quantify complex visual signatures formerly hidden in the responses of the eyes. This allows caregivers, when presenting these images to people to be evaluated for a condition, to identify, again with eye-tracking and software analysis, those signatures indicative of a presence or an absence of the condition. An associated remediative response provides treatment applicable to a real-time environment.