K. Raja Reddy,Jeff Stebbins,Serge H. Boyer,Mark D. Erion,Scott J. Hecker,Nicholas Brian Raffaele,Brett C. Bookser,Venkat Reddy Mali
申请号：
US14628373
公开号：
US09340566B2
申请日:
2015.02.23
申请国别(地区):
US
年份:
2016
代理人:
摘要：
The invention pertains to the use of fused bicyclo heterocyclic adducts of thiohydroxy pyridines or pyrimidines as diacylglycerol O-acyltransferase 1 (DGAT-1) inhibitors to treat hyperlipidiemias and various diseases and disorders associated therewith. Other conditions also can be ameliorated or avoided, such as high postprandial triglycerides or diet-related hypertriglyceridemia, cardiovascular risk associated with excessive triglycerides, and insulin resistance/glucose intolerance in overweight patients, those with diabetes or other glucose metabolic disorders such as Syndrome X and/or polycystic ovary disease.
