K. RAJA REDDY,JEFF STEBBINS,SERGE H. BOYER,MARK D. ERION,SCOTT J. HECKER,NICHOLAS BRIAN RAFFAELE,BRETT C. BOOKSER,VENKAT REDDY MALI
申请号：
US15151740
公开号：
US20160263132A1
申请日:
2016.05.11
申请国别(地区):
US
年份:
2016
代理人:
摘要：
The invention pertains to the use of fused bicyclo heterocyclic adducts of thiohydroxy pyridines or pyrimidines as diacylglycerol O-acyltransferase 1 (DGAT-1) inhibitors to treat hyperlipidiemias and various diseases and disorders associated therewith. Other conditions also can be ameliorated or avoided, such as high postprandial triglycerides or diet-related hypertriglyceridemia, cardiovascular risk associated with excessive triglycerides, and insulin resistance/glucose intolerance in overweight patients, those with diabetes or other glucose metabolic disorders such as Syndrome X and/or polycystic ovary disease.
