The United States of America;as represented by the Secretary;Department of Health and Human Services
发明人:
Haiying Qin,Crystal L. Mackall,Terry J. Fry
申请号：
US16613187
公开号：
US20200147134A1
申请日:
2018.05.15
申请国别(地区):
US
年份:
2020
代理人:
摘要：
An embodiment of the invention provides bicistronic chimeric antigen receptor (CAR) amino acid constructs. Nucleic acids, recombinant expression vectors, host cells, populations of cells, and pharmaceutical compositions relating to the CAR constructs are disclosed. Methods of detecting the presence of cancer in a mammal and methods of treating or preventing cancer in a mammal are also disclosed. Methods of making the CAR constructs are disclosed.
