Bernhard KREYMANN,Christoph HÜSSTEGE,Catherine Elisabeth SCHREIBER
申请号：
MX2018010947
公开号：
MX2018010947A
申请日:
2016.03.14
申请国别(地区):
MX
年份:
2019
代理人:
摘要：
The invention provides a method and an apparatus or system for dialysis. The method and apparatus or system are useful for removing an undesirable protein-binding substance such as a toxin from a biological fluid such as blood or blood plasma. As such, the method and apparatus or system are useful for treating a subject in need of dialysis such as a subject suffering from hepatic disease. The methods feature a) dialyzing a biological fluid against a dialysis fluid containing an adsorber for a protein-binding substance to be removed through a semipermeable membrane, b) adjusting the dialysis fluid so that the binding affinity of the adsorber for the protein-bound substance to be removed is lowered and the substance to be removed passes into solution, and c) balancing the volume or flow of one or more fluids in the apparatus or system suitable for dialyzing a biological fluid containing a protein-binding substance to be removed. The apparatus or system features a) a biological fluid circuit (3)； b) a dialysis fluid circuit (2)； c) a means (4； 6； 7； 8； 9) for solubilizing the protein- binding substance to be removed； d) a dialysis, filtration or diafiltration device (5)； e) a balancing system or apparatus suitable for balancing the volume or flow of one or more fluids in the apparatus or system suitable for dialyzing a biological fluid containing a protein-binding substance to be removed； and f) a dialysate regeneration unit.La invención proporciona un método y un aparato o sistema para diálisis. El método y aparato o sistema son útiles para remover una sustancia indeseable que se enlaza a proteínas tal como una toxina de un fluido biológico tal como sangre o plasma sanguíneo. Como tal, el método y aparato o sistema son útiles para tratar un sujeto que necesita diálisis, tal como un sujeto que padece una enfermedad hepática. Los métodos presentan a) dializar un fluido biológico contra un fluido de diálisis que contiene un adsorbente que va a remover una sustancia que s
