KREYMANN, Bernhard,HÜSSTEGE, Christoph,SCHREIBER, Catherine, Elisabeth
申请号：
IBIB2016/000287
公开号：
WO2017/158392A1
申请日:
2016.03.14
申请国别(地区):
IB
年份:
2017
代理人:
摘要：
The invention provides a method and an apparatus or system for dialysis. The method and apparatus or system are useful for removing an undesirable protein-binding substance such as a toxin from a biological fluid such as blood or blood plasma. As such, the method and apparatus or system are useful for treating a subject in need of dialysis such as a subject suffering from hepatic disease. The methods feature a) dialyzing a biological fluid against a dialysis fluid containing an adsorber for a protein-binding substance to be removed through a semipermeable membrane, b) adjusting the dialysis fluid so that the binding affinity of the adsorber for the protein-bound substance to be removed is lowered and the substance to be removed passes into solution, and c) balancing the volume or flow of one or more fluids in the apparatus or system suitable for dialyzing a biological fluid containing a protein-binding substance to be removed. The apparatus or system features a) a biological fluid circuit (3)； b) a dialysis fluid circuit (2)； c) a means (4； 6； 7； 8； 9) for solubilizing the protein- binding substance to be removed； d) a dialysis, filtration or diafiltration device (5)； e) a balancing system or apparatus suitable for balancing the volume or flow of one or more fluids in the apparatus or system suitable for dialyzing a biological fluid containing a protein-binding substance to be removed； and f) a dialysate regeneration unit.L'invention concerne un procédé et un appareil ou système de dialyse. Le procédé et l'appareil ou système servent à éliminer une substance indésirable se liant aux protéines telle qu'une toxine d'un liquide organique comme le sang ou le plasma sanguin. A ce titre, le procédé et l'appareil ou système sont utiles pour traiter un sujet ayant besoin d'une dialyse tel qu'un sujet souffrant d'une maladie hépatique. Les procédés comprennent a) la dialyse d'un liquide organique contre un fluide de dialyse contenant un adsorbeur pour une substance se liant
