Novel small molecule compounds for reduction of A&bgr; 42 production and for treatment of Alzheimer′s Disease and other neurodegenerative disorders, methods of making them and pharmaceutical compositions containing them are described.Aβ生成の低減およびアルツハイマー病および他の神経変性疾病の治療のための新規な小型分子化合物、その調製方法、並びにそれを含んだ薬剤組成物。