Matthias W Rath,Aleksandra Niedzwiecki,John Chang-Eun Cha
申请号：
US14025532
公开号：
US09018437B2
申请日:
2013.09.12
申请国别(地区):
US
年份:
2015
代理人:
摘要：
The invention discloses novel model of transgenic mammal, a method of crossbreeding transgenic mammal and the use of the transgenic mammal for assessing prevention and/or treatment methods for cardiovascular and other diseases related to lipoprotein(a). The transgenic mammal expresses human apolipoprotein (a) (apo(a)) and human apolipoprotein B-100 (apo B-100) genes and produces human lipoprotein (a), apo (a) and apo B-100 and produces no vitamin C. This novel dual transgenic mammal is the ideal model for testing pharmaceutical compounds for efficacy and usefulness in the prevention and/or treatment of human diseases.
