TRANSGENIC MICE EXPRESSING HUMAN LIPOPROTEIN (A) WITH DISCONNECTED VITAMIN C GENE, AND THEIR USE AS A DISEASE TREATMENT MODEL

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专利权人:

发明人:

申请号：

RU2015113820

公开号：

RU2015113820A3

申请日:

申请国别(地区):

RU

年份:

2018

代理人:

摘要：

The invention discloses novel model of transgenic mammal, a method of crossbreeding transgenic mammal and the use of the transgenic mammal for assessing prevention and/or treatment methods for cardiovascular and other diseases related to lipoprotein(a). The transgenic mammal expresses human apolipoprotein (a) (apo(a)) and human apolipoprotein B-100 (apo B-100) genes and produces human lipoprotein (a), apo (a) and apo B-100 and produces no vitamin C. This novel dual transgenic mammal is the ideal model for testing pharmaceutical compounds for efficacy and usefulness in the prevention and/or treatment of human diseases.

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中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/