IFN-α fusion protein comprising interferon-alpha and cytoplasmic residual cell membrane penetrating peptide

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专利权人:

ジェイダブリュ ファーマシューティカル コーポレーション

发明人:

リー・チャン キュ,ヤン・ソニョン,カン・ウン ジュ,リュー・カン,リー・ヒュン スー,ペ・ヨン スー

申请号：

JP2012501917

公开号：

JP5576928B2

申请日:

2009.03.27

申请国别(地区):

JP

年份:

2014

代理人:

摘要：

Disclosed is an interferon-± (IFN-±) fused protein having IFN-± fused to a cytoplasmic transduction peptide (CTP). The disclosure relates to a fused protein wherein a CTP, which binds well to cell-membrane barriers and enables translocation into the liver, is genetically fused to a human IFN-±, thereby enhancing the conjugation capacity of cell membranes and antiviral activity, inhibiting CTP transport into the cell nucleus, and enhancing the translocation and settlement of the fused protein into the liver and of transduction to the liver tissue. Accordingly, it is possible to develop protein-based medicines effective for preventing or treating various liver diseases associated with viral infection at low doses.

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