Chan Kyu Lee;Kang Ryu;Ju Kang;Yong Soo Bae;Seonyoung Yang;Hyun Soo Lee
发明人:
Chan Kyu Lee,Seonyoung Yang,Ju Kang,Kang Ryu,Hyun Soo Lee,Yong Soo Bae
申请号：
US13260490
公开号：
US20120134961A1
申请日:
2009.03.27
申请国别(地区):
US
年份:
2012
代理人:
摘要：
Disclosed is an interferon-α (IFN-α) fused protein having IFN-α fused to a cytoplasmic transduction peptide (CTP). The disclosure relates to a fused protein wherein a CTP, which binds well to cell-membrane barriers and enables translocation into the liver, is genetically fused to a human IFN-α, thereby enhancing the conjugation capacity of cell membranes and antiviral activity, inhibiting CTP transport into the cell nucleus, and enhancing the translocation and settlement of the fused protein into the liver and of transduction to the liver tissue. Accordingly, it is possible to develop protein-based medicines effective for preventing or treating various liver diseases associated with viral infection at low doses.
