The present invention relates to Eutectic Mixtures (EM), and preferably Deep Eutectic Solvents (DES), that are used in or as oral pharmaceutical formulation platforms. These platforms improve the solubility and bioavailability of active pharmaceutical ingredients (API), and especially of poorly water-soluble APls. The deep eutectic solvent (DES) compositions of the invention make use of a combination of propylene glycol With a polymer solubilizer component in specific molar ratios.