Alejandro Fabio Scasso;Francisco Jose Evaristo Stefano
发明人:
Alejandro Fabio Scasso,Francisco Jose Evaristo Stefano
申请号：
US14240632
公开号：
US20140221942A1
申请日:
2012.08.21
申请国别(地区):
US
年份:
2014
代理人:
摘要：
The present invention pertains generally to the field of transdermal drug delivery. More specifically, the invention relates to a device for the transdermal delivery of an alkaline pharmaceutically active compound that is susceptible to degradation in its free base form (e.g., rivastigmine) that comprises an adhesive matrix layer, a backing layer and a release or protective layer, wherein the adhesive matrix layer comprises said pharmaceutically active compound, triethylcitrate and hydrochloric acid. The invention also relates to methods of preparing such devices.
