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Growth hormone and interferon-alpha 2 glycoproteins produced in plants
专利权人:
Ohio University
发明人:
Marcia J. Kieliszewski,Jianfeng Xu,John Kopchick,Shigeru Okada,Gary Meyer
申请号:
US13855946
公开号:
US08962811B2
申请日:
2013.04.03
申请国别(地区):
US
年份:
2015
代理人:
摘要:
Methods of increasing the yield in plant expression of recombinant proteins comprising engineering glycosylation sites into cloned genes or cDNAs for proteins using codons that drive post-translational modifications in plants; and engineering the cloned genes or cDNAs to contain a plant secretory signal sequence that targets the gene products (protein) for secretion. The methods result in increased recombinant glycosylated protein yields. Proteins produced according to these methods are disclosed.
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