THE GOVERNMENT OF THE UNITED STATES; AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES; NATIONAL INSTITUTES OF HEALTH
发明人:
FELBER, BARBARA K.,PAVLAKIS, GEORGE N.
申请号：
CA2636111
公开号：
CA2636111C
申请日:
2007.01.12
申请国别(地区):
CA
年份:
2018
代理人:
摘要：
The present invention provides for nucleic acids improved for the expressionof interleukin-15 (IL-15) in mammalian cells. The invention further providesfor methods of expressing IL-15 in mammalian cells by transfecting the cellwith a nucleic acid sequence comprising a codon optimized IL-15 sequence. Thepresent invention further provides expression vectors, and IL-15 and IL 15receptor alpha combinations (nucleic acid and protein) that increase IL-15stability and potency in vitro and in vivo. The present methods are useful forthe increased bioavailability and biological effects of IL-15 after DNA, RNAor protein administration in a subject (e.g. a mammal, a human).
